When I encounter a profile that could benefit from more bite I sometimes prefer to use a Treble Booster in front (clearing up the low end before distortion) instead of boosting the highs/cutting the lows post distortion with EQ.
The way I set the Treble Booster right away is:
Tone: -5
Ducking: 0
Volume: 0
this is basically the TB in it's neutral setting.
now I slowly increase the Tone setting until I find my sweet spot.
tip: strumm a few open strings repeatedly while turning the Tone knob with your other hand and don't even look at the display - just listen.
do the same for volume, but this time I'd recommend starting from 0 and turn it both ways till it sounds good.
the eyes can sometimes confuse the ears.