John Mayer - I don't trust myself guitar sound

uhm.....don't know exactly but sounds like a synth like FX, i.e. a guitar sounding like a synth.

check Bill Ruppert profiles which are outstanding in soundsing like synth, maybe if you start from there you'll get to it.

sounds like it has no attack, though. it shouldn't be too hard to get it.

michael

Maybe by setting the noise gate to 10, pick parameter and definition to 0 and putting a vowel wah in the stomp section you can achieve something similar

He uses a Signature 2 Rock amp with a wah pedal. Not sure which pedal. Oh and a strat with singles. Nothing too complicated.

You can get something similar by using a wah or EQ/Filter, set to 100% effect, and play with the "Ducking" parameter to make the filter sweep up from sub audible to hollow sounding, with each pluck.