Rig volume. Often overlooked and under-estimated. Sometimes it's a combination of a guitar pickups characteristics that make it clip (Red LED) for some people and not for others. Don't be afraid to lower rig volume and save over a profile. This way, you will not be changing any of the character of the profile, just lowering it's volume and creating the headroom you need.
This!
And don't forget to look at the cab volume as well.
i have seen rigs where this was set unnecessarily high.