(This might be obvious and there might be a way for Rig Manager to do something similar, but I'm not an expert at Rig Manager.)
As I set up a new set of rigs (Performance slots) for a new guitar (Strat with SD Little '59 in the rear, normal SCs in the front and middle) I'm always after the "best" clean, crunch, and soloing tones.
I find it easier to set up a Performance with the top 5 clean (or crunch, or soloing) tones I can find. I'll then switch back and forth among the 5 to find the best one I can. I might save the winner and load 4 more to see if I can get better tones. I find this better than just going through Rig Manager and trying random rigs (although I might do that just to find some to load into my test Performance slots).