I´m a total rookie here but from what I experienced so far, I´ll stick to my 1x12 TAD cabinet with the Celestion Gold speaker in it.
This cabinet sounds just great with whatever amp I used ( Friedman Small Box, Friedman Pink Taco, Marshall 2061, BlugGuitar Amp1)
So it does with my Camplifier 180-equiped Toaster 
But in any case it´s finally only for the boys in the band. 
Due to severe hearing problems I will use IEM anyway...live on stage!! Alone in my room there´s no problem so I can dial in my tones 
Yet knowing that my sounds are great is a relief