From time to time I have had issues with excessive noise in my setup. At one point cleaning up all the excess cables and keeping the power cables away from the instrument/line cables really helped.
This weekend I found another source of the noise. My Kemper sits on my power conditioner which I have a cell phone charger plugged into. I needed to plug in my phone so I inserted the usb cable into the charger with out even plugging the phone in and on came the noise, unplug the usb and the noise was gone, so time to find a new spot for the phone charger.