I've been working a lot with direct (no cab) profiles of my own gear lately running them through a matrix power amp and then through my guitar cabs.
I've found that when I dial up an amp (I have several very nice high end amps I've collected over the years) through a cab the way I like it, then profile just the amp (no cab, direct profile) and then run the KPA profile through the matrix power into the guitar cab I cannot tell a difference from the original amp... it's as perfect as my ears can perceive.
What I wonder about, however, is if the same is true for your profiles because they are all studio profiles and not merged - meaning that a little of the amp gets into the cab block and a little of the cab gets into the amp. The separation is not perfect and I've read about it in other places here on the forum (as well as experiencing it myself.)
So I wonder if you'd get better results using a direct profile through your cab as opposed to a studio profile with the cab block turned off?