I have the powered rack which I typically run into a Marshall 2061CX handwired 2x12 cab and I use a variety of guitars, one of which is a Custom Classic Strat fitted with Joe Barden S-Deluxe humbucking pickups. After working with this combination for some time and trialling hundreds of profiles, I still feel I am not getting the best Strat tones. (My Strat references are many but basically think of SRV or any sweet detailed breakup/crunch tones for blues type playing.)
At this point I don't have any other Strats for reference but it occurred to me that maybe the Bardens aren't reproducing the kind of detail on the lower strings that a good single coil does. Basically, notes on the lower strings always sound muddy to me, whereas I feel it should still have twang and bite down there.
I'd be interested to know which profiles on the exchange are rated highly for this style by other Strat users, so that I can check them out. I'm going to try and borrow my mate's Strat also at some point for further reference.