For me, the most elusive tone has been Santana's (Supernatural era), probably because it is extremely amp dependant. I've seen many get a bit close, but in reality they are coming up with a variant of the woman tone that is more Clapton and less Carlos.
I'm looking for something in the same ballpark as this (interestingly, he's not using a PRS):
https://www.youtube.com/watch?v=u8H8e0T79Fc
Are there any profiles out that are able to get you there?