They (as many other commercial and non-commercial rigs do for me) hum big time, at least with my humbucking PRS's, and I can't stand hum.
As MM says, it must be your guitar. None of my PRS hum with any of the profiles I use (including Michael's).
I also add delay and a higher reverb mix as others have mentioned.
The first thing I do with nearly all profiles is turn off the delay and massively reduce the reverb. Tone Junkie are particularly bad for this. By the way, I actually love their profiles and have a few packs but they use WAY too much reverb for my taste. The good news is it's dead easy to adjust that sort of stuff to taste