I'm a new Kemper owner and have been learning my around the device. I had heard that it's not recommended to tweak the profile too much, but then listened to some great podcasts from Tone Junkie and Michael Britt dispelling that.
In that spirit, I used Michael Britt's free Dirty Shirley profile from the rig pack and made a patch that goes from clean to high gain lead. It sounds pretty good to me!
I've also been playing around with swapping cabs on studio profiles, which also seemed like a no-no to me but in practice sounds pretty good. The Kemper seems to break a lot of rules!