For lead sounds try a delay matching the tempo of the song. Use the tap tempo !
Care less about your tone - sound is important but 90% of our sound is from our hands and the only people in the audience really listening to your guitar tone are other guitarists...who won't like what you play regardless. Plus your ears/perception change constantly, even if you sound stays consistent
Avoid analysis paralysis - don't search for sonic nirvana, it leads to endless disappointment. Settle for 90%..
I rarely use eq, as said by others I tend to go for a good sounding profile and stick with it.
This. It's just as true for a profiler as it is for every other piece of gear you have.