How will the Kone software treat Direct Amp profiles? Will it be auto on or?
That's what the manual will tell:
You probably use Direct Profiles in your live set, such as acoustic guitar sounds or bass rigs. Direct Profiles are marked by having the Cabinet Module set to „empty“, thus featuring a full range sound. Running a full range sound through a classic guitar speaker is unpleasant. Therefore, in speaker imprint mode (MonitorCabOff active), when switching to a Direct Profile, Kemper Kone will automatically switch to full range mode for that rig. No preparation needed.