Couple of comments from me:
1) The infamous AC20 profile....I tried it and could see what the excitement was all about. My ears are clearly full of wax and I need to revisit it.
2) One Amp - previously I had one amp profile for solo ( mesa), one for Rhythm ( Marshall), one for clean (JC120). I've changed slightly in using one amp for Rhythm and solo to avoid ear shock for users, but a clean sound generally is different and hence is quite normal change. I hasten to add I'm not a pedal gain type of person and I don't think I ever will be. I also agree just because we have the ability to have 15 profiles per song, doesn't mean you should. So for me, this is the perfect balance.
I tend not to use a clean amp with pedals for dirt. But I will use a drive or fuzz to augment an already edgy/dirty amp to get more gain or a different timbre from the distortion. Kind of like getting a soda from a Coke Freestyle dispenser. It's Coca Cola (or whatever).....with a little something else for variation and options.