I tweak everything constantly. I've always been that way with everything from tube amps to plugins to other modelers to my current Kemper Stage. That's just me.
I've found that with the Kemper, I rarely have to tweak a clean or edge-of-breakup amp. Maybe dial in some extra gain or presence. With high gain profiles, I have to tweak a lot.
Part of that is I have very specific sounds I'm after with high gain rhythm tones. I like a boosted amp for tight low end, but not too much gain. I want chug, but not grind or fizz. I like a little bit extra 500-700k mids, and a big punch in the face of upper mids. I want depth and thickness, but not boominess. Then for recording, I want two slightly different profile sounds to quad track with.
Then there is so much variation with most high gain amps. Take a newer Mesa Dual Recto for example. In addition to cabs and mics, there's the orange channel in raw, vintage, and modern modes, and the same for the red channel. There could be a boost in the profile, or maybe different power tubes. Holy shit, so many different settings that create so.many different profiles out of one amp. And Rectos in particular have a huge EQ range, so there's that too... Oy.
Also, I've found that the person profiling the amp makes a big difference. Michael Britt, for example, makes great clean and crunch profiles because that's what he plays mostly with his country band. His high gain profiles, like his 5150 III are ok for leads, and sound good in general, but you have to really dial in extra boost, definition, and input sense to make them chug. Other 5150 III profiles by people like Lars Luettge chug right out of the (virtual) box.
Anyways, all that to say that the whole "don't tweak a profile" thing just doesn't work for me. I wouldn't just pass on a tube amp if it didn't sound like I wanted it to without tweaking it, so why would I do the same with a profile?
You can tweak if you want to. You can leave your friends behind. If your friends don't tweak and if they don't tweak, then they're no friends of mine.