As people have said already, it sounds pretty good. The fizz usually lives around the 3-5 kHz range. 5k and up gives you the pick attack and "airy" sound.
THINGS TO TRY:
M.Britt usually uses his P90s when making profiles. He may have used Humbuckers since these are a little more gain than normal for him. If you are then using Single Coils the amp will sound gritty and bitey, since it is tuned to the humbuckers. I would roll the AMP DEFINITION down. Too much and it will get real bassy and you will lose a lot of the pick attack. Which is another thing you mentioned. The AMP DEF really changes the sound of the pickups/profile so make large adjustments to find where your limits are, and then make slow adjustments to find just the right tone. There will be a small sweet spot.
Next I would try a little EQ. Generically set Presence on AMP EQ to about -2.3. Then bring the Hi/Treble up a little to get some brightness back. You may need to adjust the MID down a touch if it sounds too dark/muddy after killing the highs. After playing a while you may bring the Presence back up a little.
Next attempt would be to switch the AMP EQ to PRE. This will let you tweak the pickup response using the AMP EQ. Then add a studio EQ after the AMP. This will give you total control of the fizz and attack. The 3rd filter should be set around 3.3 kHz with a large Q and roll the gain down to reduce the fizz. I normally set the HI filter to around 800Hz and add a little gain to bring the brightness back.
AMP GAIN
Another thing to try might be rolling the AMP GAIN down a touch. A lot of profiles get fizzy/scratchy when you add more gain than the profile started with. Then you need to add a pedal to get some gain back in a cleaner way. Having a pedal and some AMP DIRECT MIX always results in a more dynamic sounding profile.
A Compressor before the AMP set to 4.5, 2.6, 85%, 1.0 is a good place to start. Dial the 4.5 up/dn for gain and the 2.6 up/dn for pick attack. The 1.0 gain can also be up/dn for gain, but this pushes the amp more like the gain control on the amp so it may result in the fizz coming back.
A pure DS pedal with gain set around 2 gives a decent push without mangling the tone.
CABINET
Sometimes the CAB in the profile just sounds wrong to you. And no amount of EQ will fix it. I would try some different CABs. This will squash that fizz before it even exists. I posted a DSL40 cab I made on here some place that sounds pretty good. There is also a FENDER DELUXE profile on the RE that has a great CAB. M.Britt has a great Rockman profile that has a darker sounding CAB that may work great for this Marshall tone and Single Coils.
I have found when making profiles that the guitar used is key to the result. The bridge pickup has more mids, the neck more hi/lows. This imprints into the profile. Bridge will sound smooth and the neck will sound bassy and fizzy. So you can look thru the RE for amps that used humbuckers in bridge position (99% of gain profiles) and swap those CABs with yours in RM.
SUMMARY:
Your tone sounds amazing. Great playing also. Sounds like you are really close to where you want to be.