Stumbled across something last night that I wanted to double check this morning with fresh ears and it's confirmed. Every single one of the 12 rigs I loaded the last couple of days sounds best with 0.00 compression in the amp stack. At first I thought it was just the cleaner amps but it's everything from crystal clean to smoking dirt. I do use a little compression (always on) to help smooth things outs right after the guitar so the stacking is the issue.
This is now on the checklist with every new rig.
As with everything this is a matter of personal taste and depending on the amp that’s profiled I have a totally different opinion about this.
Note that when profiling the amp compressor will always be set to zero.
Dialing in some amp compression fine-tunes the amp and helps (in some cases dramatically) it to clean up better when dialing back the volume on the guitar. In many cases one trick pony distortion amps suddenly become very capable allrounders that let me control everything with my guitar. IOW the responsiveness of an amp can be vastly improved.
I go as far as to say that the Profiler's amp compressor (no other modeller has it btw) is one of its best features. 
