Technically, RME build great devices. But there's always some downsides you need to be aware of.
1. Microphone Inputs (XLR connectors) on front panel only.
I hate to have cables in front of me on my desk or on the front side of a rack.
2. Power switch on the back side.
C'mon how stupid is this in terms of usability?
3. No phones level poti (wtf?)
4. Hardware access to input channel gain (Level) less than optimal.
5. TotalMix software is powerful but quite a bit confusing craziness on screen.
I decided to go Focusrite many years ago, starting with Saffire Pro 26 i/o and now Liquid Saffire Pro 56 and for mobile use with tablet PC or notebook I have a Scarlett 2i4. Great quality, great driver support, perfect usability for me.