The smaller you go with the woofer size and the enclosure size, the less bass response you get. While this might not be a huge issue when you play electric guitar only ... you'll likely notice it quite a bit when you e.g. play over a backing track with bass and kick drum/floor toms.
Regarding "guitar only", I don#t know what genre you typically play. But don't expect such small speakers to "chug" properly (this plam muted ooomp in high gain).
I play Yamaha THR30II with two 3.5" speakers and maybe they don't deliver punch of 12" speaker, but I play over backing tracks ant it sounds damn good. I created a request for Kemper Desktop Amp, but they moved it to other gear. Well. I play other gear then. I don't play Kemper