Another trick that works good, especially on high gain sounds, is to set the volume of the profile to your solo level initially, then use an effect (like the EQ) to lower the volume for rhythm. Then save the profile with the effect engaged. When the solo comes around, you disable the eq. to put the volume back at the original level.
Kind of like boosting without actually boosting. It can help on profiles that get noisy when boosted too much.