I saved few preset in the input section, one for each of my guitars, and I always keep the input locked.
Every time I switch guitar during the concert I just long press the input button and rotate the knob to chose the right input preset.
The input presets are sort alphabetically so I use a character in front of the name of the guitar (a-Tele, a-LesPaul, etc) to keep close the presets I use in the same concert.
Just use a good method to refine clean and distortion sense and you can use the same performances with many guitars in the same gig ?