Pushing 9db extra into any profile will make them sound different. Try to just raise the gain some notes and see what happens.
This is IMO what the dist sens is for and you can save different input presets for each guitar if you'd like.
Personally I would use individual rigs tailored for each guitar though.
And comparing single coils to humbuckers is also hard. One is not 'better' than the other but they sound different.