It has taken me a very, very long time to make my brain FRFR friendly. Part of the problem was that I was trying some FRFR units that were not what they seemed. I've always been a cabinet user.
That being said, I had a chance to rent some gear this weekend and I've come to the conclusion that even with the 3.0 and merged profiles, the ones that I use are of the heavier variety and they still sound similar through a guitar cabinet. There is some differentiation but after trying a good FRFR (Line 6 L2M), I've found that it works beautifully and I get the tones I want, can crank it up and it just sounds amazing!
I am still wanting to try either a DXR10, DXR12 or DSR12 from Yamaha. Hopefully I can find one to rent and try as well.