So I've messed a bit with one profile I took from my Laney VC100 and here are my findings:
First and most obvious, when a profile sounds harsh and shrill, adding bass and/or mids helps. A comfortable tone is often the result of balanced frequencies content, if that makes any sense.
So here are the things I've tried:
1. Added some bass and midrange in the EQ block (note that for that to work with the DXR10 it has to have the 100Hz low cut engaged otherwise it will sound too boomy)
2. Shaved off some presence in the EQ block, set to -2.0 in this rig
3. In the amp block, reduced some of the "pick" parameter. String noise is what annoys me the most in a guitar tone, it's what I find the most distracting and uninspiring so I have this set to -1.5
4. Still in the amp block, lowered the definition from 10.0 to 6.8
5. Yet another amp block parameter, added some power sagging, around 1.5 so the bass notes will "breathe" a little and have more punch
6. The delay block needs to be adjusted in order not to introduce some unwanted high frequencies - not sure why this happens, but it does. So I usually set bandwidth to 3.8 and keep the mix around 35% with a bit of ducking (0.3 - 0.4)
7. I often put a Green Screamer in front of the amp in order to get a more creamy distortion with more harmonics, but I used to keep the tone control too high (at -1.2), adjusting it to -2.2 makes it sound much better. Also the volume at 0.0 makes the rig sound a bit anemic depending on the amp so in this particular rig I set it to +0.5
8. I set the clean sense at 2.5 for the guitar I'm using (an Ibanez RG1570 with a DiMarzio Fred in the bridge and a PAF 36th anniversary in the neck), I usually set clean sense so the input LED barely lights yellow when I strum hard
After doing all this I got a pretty usable tone, dare I say fairly closer to the real thing. Tomorrow I might try taking new profiles of my amps.