I have some quick tipps, perhaps they are useful. They can work but not in every situation.
- Use a DI track for editing. It's much easier to see where the pick hits the strings in the DI track as in the amp track.
- More distortion means less compression is needed because the distortion of the amplifier has also a compressing effect.
- Sometimes a basic limiter can work wonders on the guitar just to tame the highest peaks.
- If there is some annoying whistle in the sound roll the areas off with an EQ with a high Q factor just to get rid of this single frequencies. This works also really well with a dynamic equalizer.
- Too much bass or too hot palm mutes can be tamed with a multiband compressor only working in the bass area