Hmmm....I'm guessing you've already tried some other profiles/variables in the signal chain?
Sometime on profiles I am checking out for lead sounds (in particular) when you bend a note it sounds like there is a weird swirling underneath it - a bit like if you are playing a unison bend that is intentionally dissonant...
Sometimes turning the modulation down or off in the the delay helps - sometimes there is something weird in the delay if it is set for stereo and you are monitoring in mono (without adjusting outputs)...if there is no delay on the profile - I have always thought it has just been profiled badly and move on.
Not sure what else it could be...just as overall checks - is space turned off and is monitor cab off when you are using your real cabinet?
Hope that helps mate - if not - please post an audio clip and I'll have a listen.