@CK is relaxed because he knows "normal people want what the superstars have".
For neural to break into this world (of really big names using the qc for touring) will be not easy.
I'd not say that. The product is aimed at 15-30 market range (I've made it up). It's generic design is very similar to an iphone. Their VST plugins are kind of legendary (I personally think no VST sounds better than these plugins).
I guess, depends on what you define as "big names". For QC target market, big names are Pilni, Abasi, Nolly and Gojira. If I were AxeFX, I'd be very concerned 
I doubt Mark Knopfler will be using it tho.
Me personally, after seeing latest Rabea video, I'll go an try it (it's very easy for me). Usually I'd not even bother trying things like Helix etc.
I am not sure how long current gen QC will be relevant. If they come up with v2 in 2 years... I've been spoiled by CK strategy and having the same unit for 7+ years now.
CK created a classic, like Marshall, it took 10 years for something comparable to come out. Nobody is going to be able to top it, improve yes, but top, no.
Let's see if we have another guitar product from CK.
btw. many of those videos seems to have the same script, ending up with comparison to Kemper. I wonder if it came in QC box. 