Besides all these very good recommendations here in the Forum I'd like to ammend another aspect for a newbie to "Tweaking the KPA"
It's different to tweak the KPA compared to tweak a real Amp with Cabinet, because the KPA has a Pretty bunch of more Parameters which a real amp misses. But as already said above, you don't Need them all to achieve your sound-immaginations. There are Parameters which are more important and have a more intense Impact to the Sound (f.e. Amp-Definition, Cab-IRs, Amp-EQ and Stomp-EQs) than others. I personally needed a bit of time to get used to these parameter and their specific impact to the Sound.
I always need to be Aware , that I don't listen to the amp's-in-the-room-sound when tweaking my KPA-live-Sound on our P.A.-System.
On a real amp you normally just have gain-, volume- and EQ-knobs and sometimes presence and that's it. The rest is influenced by the cab's charackteristics with it's Speaker inside and reacts less intense and in a way smoother than the KPA.
For example changing from a Strat-type guitar to a Les-Paul-type on a real amp, I just tweak the Gain-, The Treble- and the Bass-knob a bit. With the KPA I always first look what is active in the current Profile (Amp, Cab, Stomps, Output-EQ, Clean-/Distortion-Sense) before I choose a Parameter to adjust the Sound, because the different parameters interact between each other with partially huge effects to the sound.
This affords a bit of experíence and may cause a bit of confusion especially in the beginning-phase and also in stressful live-situations.
So finally I urgently recommend to tweak intensively just at least to become experienced to the KPA's capabilities and These are HUGE !!
And also to have a lot of fun with your Approach to your personal Dream-Tone. 