I play my powered KPA thru an old Marshall straight 4 x 12 with mixed vintage celestions - sounds amazing. In the effort to keep live rig simple I use one "Rig", with Liquid foot MIDI controller (8 button) and 3 expression pedals. I only use 4 of the buttons, L to R, "tap tempo", "tuner", a seldom used "clean" rig and finally my main Rig - the "Sea Nymph" profile with a cab profile I love.
The expression pedals, L to R: Delay Mix, Volume (set for 5bd range) and a "switchless Mission Pedal for "wah".
This makes for zero tap dancing and is incredibly easy to drop in spot leads etc. I'm on the wah all the time and my tone is super mid-rangy, so don't feel need for separate EQ on leads. I've been so happy with the sound I haven't even updated the system for al long time... kinds scared to at this point since unclear on how kemper now handles the Cab profiles - and don't want to mess up my perfect tone!