The XLR and 1/4" Profiler outputs are line level (+4 dBu).
XLR are balanced.
1/4" are unbalanced.
If you're running cables greater than 25 feet, I would use balanced cables (XLR).
Yes, make sure the inputs on the board are set to line level.
Make sure there are no effects are enabled on the channel(s) you use on the board.