Thanks for the reply Mr. Kemper.
I don't use hardware effects at this point. I use Universal Audio Apollos running UAD plugins. I can easily set up each of two Kempers with the same effects. So that is not an issue for me.
The Apollos have more than enough DSP to handle the plugins with near zero latency. And the plugins on the UAD platform are world class quality. They are almost indistinguishable from the hardware they model.
I also plan to run stereo and hexaphonic guitar soon. I am going to modify my Hamer Duotone. It will soon have a Cycfi Nu2 Multi (hexaphonic) pickup and two Fluence Open Core classic humbuckers wired in stereo. The Fluence pickups each have three voices, which I will be able to select independently.
I want a parallel path for the Fluence pickups wired in stereo. In some cases I will be using both paths with the same effects. In some cases I will use different effects on each path.
The Cycfi hex pickup will be multed, sent dry to six separate tracks in Logic, and also mixed to stereo. The stereo signal may go through the two Kempers or into stereo Apollo Unison guitar amp sims.
Later I can manipulate the dry hex signals in all sorts of creative ways. Since this use case doesn't require real time output, I can experiment to my heart's content in my studio.