Although this should be taken with a grain of salt, I want to share this quite interesting experience:
I figured out that I wanted to sell my CLR active wedge. It sounded good but I prefer the amp in the room tone for personal monitoring. Very soon after I put it up for sale I got a text from a guy I had dealt with before. He bought an Amplifire, and he wanted to try it with the CLR to see if it was the right setup for him. I thought "yey, finally going to hear the Amplifire in person" as I was quite curious about it myself and I thought about getting one as a portable alternative to the Kemper. He had experience with the Amplifire through the poweramp and cab of his Hayden Mofo only, and he thought it sounded better with cab sim on for some reason. His first impression of the CLR was that it sounded much better than through his home rig! He browsed through a couple of presets, everything from M Britt to the Amp Factory and a few he made himself. From my perspective it sounded alright but nothing mindblowing, although better than my experience with the Helix for instance. Not totally convinced, he asked me to power up the Kemper. He is a Marshall guy like me so I found a custom profile I had made of TopJimis 68' Marshall Plexi with a Choptones V30 IR. Standing there and watching him play was a pleasure in itself, they guy looked like he was in heaven, like "ohh that's the stuff!". I showed off more Marshall profiles which I have plenty of, but I think his conclusion was made after the first chord on the Plexi profile. It probably doesn't come as a surprise that he went home with no CLR, and a few days later he sold the Amplifire. Please note that I did not play a single note through the Amplifire, and this was purely my observations. I still think the Amplifire is great, but I also think that it requires quite a lot of tweaking to get your tone.