You would have to tune to Drop D first and then go -1 on Transpose. So a d-tuna is helpful. I have a locking trem with a trem stop, so I can drop D pretty quickly with a turn of the fine adjustment screw. Best way is to tune a second guitar if it's practical in your case.
Add this one to the list: C G C G G D I recently had to play this for a theatre show along with Standard and DADGAD ... All in written notation so I was hearing different notes to the ones I was fingering. I talked to the composer about it and he said, "Yea, It's a mind fuck" ... He wasn't kidding! To answer the OP, I used a Variax.