Tom Abraham has run FOH for a who's who of rock and metal legends for decades. He knows what he's talking about. So when he says that the Kemper is the best modeler/profiler sonically but that all of them are inferior to a tube amp in the mix, I'd listen to him.
And he's not just talking about frequency response and "EQ". There's also compression and transient response at various frequencies and how those things affect the ability of the guitar to cut through the mix even though they may "sound" identical.
He's not dumping on modelers, or profilers. He's just describing his experience, which he admits completely surprised him. He thought the guitars sounded IDENTICAL when isolated, but for some reason they disappeared in the mix.
True but modelers are getting better and better. Who knows what 2019 will bring