I do this without any problems and it sounds great. I still have Kemper with Camplifier connected to the cabinet section of 2x12 Lionheart combo and whilst it sounds really great I wanted to see if I can use my old stereo HiFi speakers. I mostly wanted to do this to see if it's worthwhile considering getting studio monitors.
It not only works great but now I have a stereo sound which adds another dimension and all profiles have much more distinctive character as I don't have to remove the cab portion of each profile. Try it, I think it's awesome. Oh and to my ears it maintains high and low frequencies better at lower volumes than the 2x12 cabinet. They both sounds great but I since I have both options available I use the stereo amp almost exclusively. But yes, completely agree, personal taste and all that...