My room doesn't have very well acoustics, I have thought about that, BUT I've played with it in different & better rooms and it's pretty much the same... (plus how much of a difference does it actually make)
a massive difference to be honest. However, poor acoustics and speaker placement typically make most difference in low to low mid frequencies rather than higher frequencies. One possibility is that poor room acoustics are causing substantial frequency peaks in those ranges that effectively make the highs sound quieter than they really are. Similar to saying my amp sound dull so I must need more highs when in actual fact you just need to reduce mids or lows which are masking the highs.
I don’t know if this is the problem in your case but it can’t be discounted until you remove the room from the equation (headphones would be one way to do this).
You also mentioned that you find Live Ready Sounds profiles to sound good while Tone Junkie, MBritt etc don’t. There are plenty of profiles that I don’t like which others love and vice versa. This is hardly surprising as tone is subjective and heavily dependent on genre. It may just be that your taste is different than that of Michael or Jonathan or whoever.