I would check all the input and out put connections just to make sure there is nothing physically damaged but other than that ypu should be good to go straight away. It is possible to reset everything to factory settings but not necessary in most cases.
As for the remote just make sure all the footswitches are working and the screen isnt damaged.
I totally get where you’re coming from about the Mesa rig noth being viable. I have always been a mesa player but as I get older (50 this year) ligging them about isn’t mich fun, they are way too loud for most stages (I’m ised to having them mided anyway), cabinets are too directional which can make hearing on stage less than ideal, my own hearing has taken a battering over the years but the bigges t problem is that they are unusable at home. Most of my Boogies have master volume knobs that go - nothing, nothing, nothing, SHIT there go the windows ! I had to use attenuators to play in the house.
My wife has hearing so sensitive that she can hear me playing unplugged from the other end of the house so I REALLY NEED something that works and sounds killer at any level. Nearly a year into my Kemper journey and I haven’t looked back. It was definitely the right choice for me. To be fair I also think Axe Fx, Helix and Headrush are fantastic tools but the Kemper just felt like a better solution for my personal needs and tastes.
I am sure you will love yours when it arrives. Have fun