I would not set it on globally but use it on a per rig basis, if needed.
So uncheck it in the output and see how the specific rig sounds. If the rig needs it, activate it in the cab section for that rig only.
This way you can hear how each profile really sounds and make adjustments to taste only if needed.
Kinda like not putting salt on everything, taste it first.
Thanks! That is a great idea. I will experiment with that.