Just keep raising the block size until the artifacts are gone. You might have to go higher than 144 or maybe you can go a little lower. At 144, I am 3.6ms latency which is about 4 feet from a cab or drummer if you monitor thru DAW.
Thanks again for the reply. I've managed to solve the issue now. My main profile I use the most (a high gain Dual Rectifier was apparently too hot for the signal chain to handle. Turned down the treble boost and the cracks and pops disappeared. I'm still confused because this was not an issue before, with my regular audio interface...