On the Treeview in RM, near the bottom you should see "All Performances". When you expand that you should see two folders - My Profiler and Local Library. My Profiler has the 125 Performances that are the set physically on your profiler. There will always be 125. You can't add or delete them, you can only change what is in them. Much like patches on a synthesizer. It has some number of slots that you can set up to be whatever you want. Local Library is a set that you may or may not use. It is where you can create and maintain a large library of performances. You might later copy these Local Library performances to one of the 125 My Profiler slots if you plan on using it outside of Rig Manager. Such as at a live show.
Within Rig Manager you can always select and play rigs from any performance - My Profiler or Local Library.
To clear a performance, like one of your 125 in My Profiler, the easiest way is probably to right click it, then click Initialize Performance from the popup menu (you could also use the Edit menu item, then choose Initialize...). This sets the first slot in the performance to a Rig named Crunch (the default Kemper rig) and clears the remaining 4 slots. You can't clear slot 1 in a Performance since all performances must have something in slot 1.
To change the rig in any slot of any performance, there are a few ways to get there. First, make sure your Profiler is in Performance mode and that you have some performance selected for editing. You should see the performance is highlighted and has the headphones icon to the left of its name.
I find it easiest to open a second Window (in RM, click the Window menu item at the top, then New). A second window opens where you can now scroll through all of the Rigs in the top section of RM (the My Profiler and Local Library sections under All Rigs.). From there you can just drag a rig from the second window to the slot you want in your selected performance (whether a My Profiler or Local Library performance). You would be dragging to a slot in the upper right of you first window where you see the 5 slots in the selected performance. Or you can use Copy then Paste to instead of dragging and dropping.
Saving can be a bit odd for many of us in RM, so best to make sure you save any changes after you make them. If you've changed a Performance in My Profiler, you should see a button in the bottom right labeled Replace Performance in <whatever performance # you're editing).
I hope that helps you going.