Thanks so much for this thread. I stumbled upon it and tried the recommended connection method into my Focusrite 2i4. Been playing through a Kemper Kabinet or headphones via the profiler input.
I really like what I hear through the Focusrite via Reaper (headphones). Cabs sounds great and many IR's I gave up on have taken on new life. I had some nice studio monitors as well but sold them due to lack of use. Now I am re-thinking that addition as well.
Keep in mind this is coming from someone whose idea of recording was calling my work voicemail at night or on the weekends and letting it rip. Once it was full I would move to a teammate's number. Good times...thanks again!!