I have this same problem and most of times it occurs middle of playing, suddendly sound just stops and there's no input, input led does not light, tuner leds are off and tuner shows some solid note like there's no guitar/cable connected
Only guitar and monitors connected, same thing without anything connected, alternative input is dead also. Switching modes doesn't help, switching profiles, effects or input / output settings doesn't help, only after reboot everything works good
This happens maybe once a week if playing every day for couple hours