On that rig there's a NoiseGate 4:1 in slot C. Sounds like you 've already turned that off. I used Bypass to mean turn them off or delete them. I turned off the Compressor in Slot B and I see that the Compressor on the AMP page settings is already set to zero. Although if you want Compression, I'd try that one instead of the effect in Slot B.
The Noise Gate I'm talking about is the Noise Gate knob on a toaster. Or you can click the Input button on the Profiler or Rig Manager. You should see Noise Gate, Clean Sen and Dist Sens. That is the Noise Gate I set to about 5.3 to clean up the noise but still have a pretty natural fade out.
Then yes, lowering the Rig volume however you like should get rid of the output red lighting.
Pickup output is still going to make a difference so you'll need to find what values work for your guitar. These are what work for my Les Paul to avoid what you described.