The new AxeFX III firmware seems to offer an amp in the room feature. Still too early to judge how good it is as it was a beta release and most comments don’t really talk about the feature, but if it really can recreate the feel of an amp in the room as opposed to just an amp on a recording this will be a good for all of us over time.
The firmware change is just allowing IRs to be imported into the unit in a "non-minimum phase aligned format", if they were or are created this way. Basically, no cutting out any silence before the waveform. This lets you manually align the phase of any IR and/or adjust to other IRs if you are mixing them. Gives a lot more control over the final product, but doesn't create "amp in the room" feel. For that, you need an amp in the room.