XLR's would be balanced, but by using TS you won't activate the mic-pre's (which could be causing you issues)? The 2i2 headphone impedance is only 10 ohm, so not great. Try Main Output set to Master Stereo and "headphone Space off"(output menu), to get the space parameter in the headphones & the main outputs!
From manual:
By pressing the “Headphone Space” soft button, you can select whether it is applied to the HEADPHONE OUTPUT only, or to the MAIN OUTPUTS as well. You can also apply the Space effect to individual Rigs, rather than activating it globally in the Output Section. In this case, simply use the TYPE knob to select it in either the X or MOD effect.
Great advice,
so you're saying, use TRS cables to enable preamp (prevents degradation?)
I'm only using one TS cable atm, so I think you're saying, use two TS/TRS cables in stereo (?)
Also I think that's how I have my space setting done.
Also what does headphone link do?