How do you do it?
Best is to have the cabinet in a separate room with the option to move the mic from the control room.
If I profile in the same room were the amp is I do like this:
1 ) Record some riff and chords into a looper
2 ) Setup your preamp, connect an isolation headphone to the Kemper
3 ) Play the loop
4 ) Move your mic - until you find a great position
5 ) Profile
6 ) If the profile sounds great - fine - if not - goto 3
7 ) Take some pictures of the mic and cabinet to remember the position
8 ) Profile all the amp settings you like to profile
btw. sometimes I need different mic positions for clean and distorted sounds