I agree there is no one way to do it.
When I am just playing around I have the AFD profile across 5 slots in Performance 1. When I gig I tend to have a performance per song. I agree that there is no definite BPM when playing live and that fluxuates as the song progresses.
Now I don't play guitar live I tend to have a performance per amp which means I have a variety of tones plus I don't have to scroll through 40 versions of the same profile at various gain stages just to find the one I like.
Good thread for ideas