Fresh strings - I don’t mean that in a snarky way either. They effects of string deadening are very subtle and degrade slowly... but put a new set of strings on and voila!
I find I don’t tweak the profiles much - just find a good one and stick with it. If after a little jamming it doesn’t sound good I move on to a new one. The only things I usually tweak are a bit of presence or gain (usually turning it down) before I add on effects.
Practice never hurt either! ?