My guess is SPDIF is a completely Digital system. So the Kemper sound is converted to digital info then sent to your interface. The interface analog preamps are never used because the signal is digital thru the whole process.
Using the OUTPUT jacks means the digital data from the Kemper is converted to analog then sent to the interface. The interface preamps then read the analog data and convert it to digital information.
DIGITAL:
- Preferred method.
- No noise added.
- Signal tone/color/sound is not changed.
ANALOG:
- Tiny distortion added in the Digital -> Analog conversion then Analog -> Digital conversion.
- Noise/Hiss added from the low level analog signals.
- Possible noise added from Ground Loops.
- Signal tone/color/sound is altered by the preamps frequency response.
Most people will not hear the changes in tone from SPDIF to Analog. But some will. And many may hear the added noise.
Ground Loops come from having equipment connected to different power sources and noise that is trying to get to ground travels on the cables connecting these devices. That is why some devices have a Ground Lift switch. Digital data is not affected by this as the GL noise is usually a very small voltage.
Analog noise is present in the world due to the physics of nature. And this noise gets into the analog signal and is amplified by the preamp in your interface. This can just be as simple as noise transmitting from a low frequency light/electronic system near you to a high frequency radio/television/communication signal miles away. So digital only paths are always the better method for noise.