yes, this is the key to a better or best sound!
in addition, even this might sound too drastic, don't forget the chanche of using different cabinets.
Some of my best sounds are obtained with Mike's profiles and Till's cabs.
hang on to it! maybe you can post a sample of what you consider muddy...this might be of help to help you...
I just tried changing cabs for the first time the other day and WOW! I agree with everyone that Mike's profiles sound a bit dark on my headphones (95% of my playing at home) but sound perfect live through the PA. I am now going through a bunch of the profiles previously deemed "too dark" on my headphones and changing the cab to one of Till's and now I'm getting the tones I only dreamed of getting before. Could never find a good plexi that I liked but the 3P Plexi + Klon 2.1- (I think) with Tills 1960 Cab "A" is tonal heaven to me.
Highly recommend it for anyone who's having doubts. I bet the same goes in the opposite direction - using Mike's profiled cabs on profiles that end up being too bright live.